Painkillers with anti-depressants, even aspirin, ibuprofen and naxopren with anti-depressants. It can greatly reduce the effectiveness of the anti-depressant. Any SSRI inhibitor should not be taken with pain meds.
Do not eat Grapefruit and take anti-histamines. A compound in grapefruit alters an enzyme that helps break down certain drugs in your body. That can lead to too much of the medication being absorbed, potentially boosting side effects of those anti-histamines such as drowsiness.
Do Not Mix St. John’s Wort with The Pill. St. John’s Wort is an herbal remedy used to combat depression but speeds up the breakdown of many drugs, lowering their levels in the bloodstream. There have been related pregnancies reported by women taking The Pill and St. John’s Wort. Blood thinners and anti-anxiety pills also do not mix with St. John’s Wort.